2023

Ting-Yu Lin, Shakti Ramsamooj, Tiffany Perrier, Katarina Liberatore, Louise Lantier, Neil Vasan, Kannan Karukurichi, Seo-Kyoung Hwang, Edward A. Kesicki, Edward R. Kastenhuber, Thorsten Wiederhold, Tomer M. Yaron, Emily M. Huntsman, Mengmeng Zhu, Yilun Ma, Marcia N. Paddock, Guoan Zhang, Benjamin D. Hopkins, Owen McGuinness, Robert E. Schwartz, Baran A. Ersoy, Lewis C. Cantley, Jared L. Johnson*, and Marcus D. Goncalves*. Epinephrine inhibits PI3K alpha via the Hippo kinases. Cell Rep. 2023 Dec 4;42(12):113535. doi: 10.1016/j.celrep.2023.113535 PMID: 38060450

 Lucie Yammine; Belén Picatoste; Nazish Abdullah; Rosemary A. Leahey; Emma F. Johnson; Nicolás Gómez-Banoy; Carolina Rosselot; Jennifer Wen; Tahmina Hossain; Marcus D. Goncalves; James L Lo; Adolfo Garcia-Ocaña; Timothy E. McGraw. Spatiotemporal regulation of GIPR signaling impacts glucose homeostasis as revealed in studies of a common GIPR variant. Mol Metab. 2023 Dec:78:101831. doi: 10.1016/j.molmet.2023.101831. Epub 2023 Nov 2. PMID: 37925022

Tahj A Blow*, Anirudh Murthy*, Rahul Grover, Emily Schwitzer, David M. Nanus, Darragh Halpenny, Andrew J. Plodkowski, Lee W. Jones, and Marcus D Goncalves. Profiling of skeletal muscle and adipose tissue depots in men with advanced prostate cancer receiving different forms of androgen deprivation therapy. Eur. Urol. Open Sci. in press

Henning Tim Langer*, Samuel R. Taylor*, Mujmmail Ahmed, Tiffany Perrier, Tanvir Ahmed, and Marcus D. Goncalves. The proteasome regulates body weight and systemic nutrient metabolism during fasting. AJP Endocrinol Metab in press

Leonard Buckbinder, David J. St. Jean, Jr., Trang Tieu, Brendon Ladd, Brendan Hilbert, Weixue Wang, Jacob Alltucker, Samantha Manimala, Gregory Kryukov, Natasja Brooijmans, Gregory Dowdell, Philip Jonsson, Michael Huff, Angel Guzman Perez, Erica Jackson, Marcus D. Goncalves, and Darrin Stuart. STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts. Cancer Discovery 2023 Aug 25:CD-23-0396. doi: 10.1158/2159-8290.CD-23-0396.Online ahead of print.

Michael A Weintraub, Dazhi Liu, Raymond DeMatteo, Marcus D. Goncalves, James Flory. Sodium-Glucose Cotransporter-2 Inhibitors for Hyperglycemia in Phosphoinositide 3-kinase Pathway Inhibition. Breast Cancer Res. Treat. in press

Ezequiel Dantas, Anirudh Murthy, Shakti Ramsamooj, Andre Lima Queiroz, Maurice Hurd, Tiffany Lam, Murtaza Malbari, Christopher Agrusa, Olivier Elemento, Nasser Altorki, Timothy McGraw, Darryl Pappin, Brendan Stiles, Marcus D. Goncalves*. TIMP1 is an early biomarker for detection and prognosis in lung cancer. Clin. Transl. Med. 2023 Oct;13(10):e1391. doi: 10.1002/ctm2.1391.

Miriam Ferrer; Nicholas Mourikis; Emma E. Davidson; Sam O. Kleeman; Marta Zaccaria; Jill Habel; Rachel Rubino; Qing Gao; Thomas R. Flint; Lisa Young; Claire M. Connell; Michael J. Lukey; Marcus D. Goncalves; Eileen P. White; Ashok R. Venkitaraman; Tobias Janowitz. Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia. Cell Metab. 2023 Jun 7:S1550-4131(23)00185-7. doi: 10.1016/j.cmet.2023.05.008. Epub ahead of print. PMID: 37311455.

Johnson JL, Yaron TM, Huntsman EM, Kerelsky A, Song J, Regev A, Lin TY, Liberatore K, Cizin DM, Cohen BM, Vasan N, Ma Y, Krismer K, Robles JT, van de Kooij B, van Vlimmeren AE, Andrée-Busch N, Käufer NF, Dorovkov MV, Ryazanov AG, Takagi Y, Kastenhuber ER, Goncalves MD, Hopkins BD, Elemento O, Taatjes DJ, Maucuer A, Yamashita A, Degterev A, Uduman M, Lu J, Landry SD, Zhang B, Cossentino I, Linding R, Blenis J, Hornbeck PV, Turk BE, Yaffe MB, Cantley LC. An atlas of substrate specificities for the human serine/threonine kinome. Nature. 2023 Jan;613(7945): 759-766. doi: 10.1038/s41586-022-05575-3. Epub 2023 Jan 11. PMID: 36631611; PMCID: PMC9876800.

2022

Wan Q, Huang B, Li T, Xiao Y, He Y, Du W, Wang BZ, Dakin GF, Rosenbaum M, Goncalves MD, Chen S, Leong KW, Qiang L. Selective targeting of visceral adiposity by polycation nanomedicine. Nat Nanotechnol. 2022 Dec;17(12):1311-1321. doi: 10.1038/s41565-022-01249-3. Epub 2022 Dec 1. PMID: 36456644.

Clement CC, Osan J, Buque A, Nanaware PP, Chang YC, Perino G, Shetty M, Yamazaki T, Tsai WL, Urbanska AM, Calvo-Calle JM, Ramsamooj S, Ramsamooj S, Vergani D, Mieli-Vergani G, Terziroli Beretta-Piccoli B, Gadina M, Montagna C, Goncalves MD, Sallusto F, Galluzzi L, Soni RK, Stern LJ, Santambrogio L. PDIA3 epitope-driven immune autoreactivity contributes to hepatic damage in type 2 diabetes. Sci Immunol 2022 Aug 12;7(74):eabl3795. doi: 10.1126/sciimmunol.abl3795. Epub 2022 Aug 19.

Andre Lima Queiroz*, Ezequiel Dantas*, Shakti Ramsamooj, Anirudh Murthy, Mujmmail Ahmed, Elizabeth R.M. Zunica, Roger J. Liang, Jessica Murphy, Corey D. Holman, Curtis J. Bare, Gregory Ghahramani, Zhidan Wu, David E. Cohen, John P. Kirwan, Lewis C. Cantley, Christopher L. Axelrod, and Marcus D. Goncalves* Blocking ActRIIB signaling and restoring appetite reverses cachexia and improves survival in mice with lung cancer. Nat Commun 13, 4633 (2022). https://doi.org/10.1038/s41467-022-32135-0

Henning Tim Langer, Shakti Ramsamooj, Roger J. Liang, Rahul Grover, Seo-Kyoung Hwang, Marcus DaSilva Goncalves* Systemic ketone replacement does not improve survival or cancer cachexia in mice with lung cancer. Front Oncol. 2022 Jun 3;12:903157. doi: 10.3389/fonc.2022.903157. eCollection 2022.

 Taylor SR, Falcone JN, Cantley LC, Goncalves MD. Developing dietary interventions as therapy for cancer. Nat Rev Cancer. 2022 May 25. doi: 10.1038/s41568-022-00485-y. Online ahead of print.

Sufra R, Lookens Pierre J, Dade E, Rouzier V, Apollon A, St Preux S, Préval F, Inddy J, Metz M, Tymejczyk O, Nash D, Malebranche R, Deschamps M, Pape JW, Goncalves MD, McNairy ML, Yan LD. Diabetes Epidemiology Among Adults in Port-au-Prince, Haiti: A Cross-Sectional Study. Front Endocrinol (Lausanne). 2022 Feb 24;13:841675. doi: 10.3389/fendo.2022.841675. PMID: 35282460; PMCID: PMC8913034.

Liu D, Weintraub MA, Garcia C, Goncalves MD, Sisk AE, Casas A, Harding JJ, Harnicar S, Drilon A, Jhaveri K, Flory JH. Characterization, management, and risk factors of hyperglycemia during PI3K or AKT inhibitor treatment. Cancer Med. 2022 Feb 25. doi: 10.1002/cam4.4579. Epub ahead of print. PMID: 35212193.

Marcus D. Goncalves* and Azeez Farooki. Management of Phosphatidylinositol-3-Kinase Inhibitor-Associated Hyperglycemia. Integr Cancer Ther. January 2022. doi:10.1177/15347354211073163

2021

Taylor SR, Ramsamooj S, Liang RJ, Katti A, Pozovskiy R, Vasan N, Hwang SK, Nahiyaan N, Francoeur NJ, Schatoff EM, Johnson JL, Shah MA, Dannenberg AJ, Sebra RP, Dow LE, Cantley LC, Rhee KY, Goncalves MD. Dietary fructose improves intestinal cell survival and nutrient absorption. Nature. 2021 Aug 18. doi: 10.1038/s41586-021-03827-2. Epub ahead of print. PMID: 34408323.

Liang RJ, Taylor S, Nahiyaan N, Song J, Murphy CJ, Dantas E, Cheng S, Hsu TW, Ramsamooj S, Grover R, Hwang SK, Ngo B, Cantley LC, Rhee KY, Goncalves MD. GLUT5 (SLC2A5) enables fructose-mediated proliferation independent of ketohexokinase. Cancer Metab. 2021 Mar 24;9(1):12. doi: 10.1186/s40170-021-00246-9. PMID: 33762003; PMCID: PMC7992954.

Blow T, Hyde PN, Falcone JN, Neinstein A, Vasan N, Chitkara R, Hurd MA, Sardesai S, Lustberg MB, Flory JH, Volek JS, Goncalves MD. Treating Alpelisib-Induced Hyperglycemia with Very Low Carbohydrate Diets and Sodium-Glucose Co-Transporter 2 Inhibitors: A Case Series. Integr Cancer Ther. 2021 Jan-Dec;20:15347354211032283. doi: 10.1177/15347354211032283. PMID: 34259084; PMCID: PMC8283040.

Hope S. Rugo, Mario E. Lacouture, Marcus D. Goncalves, Joyce A. O’Shaughnessy. A Multidisciplinary Approach to Optimizing Care of Patients Treated with Alpelisib. Breast 2021 Dec 27;61:156-167. doi: 10.1016/j.breast.2021.12.016. PMID: 35016012 PMCID: PMC8749445

2020

Marcus D. Goncalves, Oliver D.K. Maddocks. Engineered diets to improve cancer outcomes. Curr Opin Biotechnol. 2020 Nov 21;70:29-35. doi: 10.1016/j.copbio.2020.10.007.

Coryandar Gilvary, Jamal Elkhader, Neel Madhukar, Claire Henchcliffe, Marcus D. Goncalves, Olivier Elemento. A machine learning and network framework to discover new indications for small molecules. PLoS Comput Biol. 2020 Aug 7;16(8):e1008098. doi: 10.1371/journal.pcbi.1008098. eCollection 2020 Aug.

John Vitarello, Marcus D Goncalves, Qin C Zhou, Alexia Iasonos, Darragh F Halpenny, Andrew Plodkowski, Emily Schwitzer, Jennifer J Mueller, Oliver Zivanovic, Lee W Jones, Karen A Cadoo, Jason A Konner.  The effects of neoadjuvant chemotherapy and interval debulking surgery on body composition in patients with ovarian cancer. JCSM Clin Rep 2020 Nov; doi: doi.org/10.1002/crt2.15

Marcus D. Goncalves, Lewis C. Cantley. A 'fast'er way to treat breast cancer. Nat Metab. 2020 Jul;2(7):559-560. doi: 10.1038/s42255-020-0225-6.

Benjamin D. Hopkins*, Marcus D. Goncalves*, Lewis C. Cantley. Insulin-PI3K signalling: an evolutionarily insulated metabolic driver of cancer. Nat Rev Endocrinol. 2020 May;16(5):276-283. doi: 10.1038/s41574-020-0329-9. Epub 2020 Mar 3, *authors contributed equally.

2019

Cindy Hodakoski, Benjamin D. Hopkins, Guoan Zhang, Taojunfeng Su, Zhe Cheng, Roxanne Morris, Kyu Y. Rhee, Marcus D. Goncalves, and Lewis C. Cantley. Rac-mediated macropinocytosis of extracellular protein promotes glucose independence in non-small cell lung cancer. Cancers 2019, 11(1), 37. 2019 Jan 2;11(1):37. doi: 10.3390/cancers11010037.

Marcus D. Goncalves, Changyuan Lu, Jordan Tutnauer, Travis E. Hartman, Seo-Kyoung Hwang, Charles J Murphy, Chantal Pauli, Roxanne Morris, E Carl Lekaye, Steven S. Gross, Kyu Y. Rhee, Lewis C. Cantley, and Jihye Yun.  High-Fructose Corn Syrup Enhances Intestinal Tumor Growth. Science. 2019 Mar 22;363(6433):1345-1349. doi: 10.1126/science.aat8515.

Cheson BD, O'Brien S, Ewer MS, Goncalves MD, Farooki A, Lenz G, Yu A, Fisher RI, Zinzani PL, Dreyling M. Optimal Management of Adverse Events From Copanlisib in the Treatment of Patients With Non-Hodgkin Lymphomas. Clin Lymphoma Myeloma Leuk. 2019 Mar;19(3):135-141. doi: 10.1016/j.clml.2018.11.021. Epub 2018 Nov 29.

2018

Goncalves MD, Hwang SK, Pauli C, Murphy CJ, Cheng Z, Hopkins BD, Wu D, Loughran RM, Emerling BM, Zhang G, Fearon DT, Cantley LC. Fenofibrate prevents skeletal muscle loss in mice with lung cancer. Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E743-E752. 

Goncalves MD, Taylor S, Halpenny DF, Schwitzer E, Gandelman S, Jackson J, Lukose A, Plodkowski AJ, Tan KS, Dunphy M, Jones LW, Downey RJ. Imaging skeletal muscle volume, density, and FDG uptake before and after induction therapy for non-small cell lung cancer. Clin Radiol. 2018 May;73(5):505.e1-505.e8.

Lundquist MR, Goncalves MD, Loughran RM, Possik E, Vijayaraghavan T, Yang A, Pauli C, Ravi A, Verma A, Yang Z, Johnson JL, Wong JCY, Ma Y, Hwang KS, Weinkove D, Divecha N, Asara JM, Elemento O, Rubin MA, Kimmelman AC, Pause A, Cantley LC, Emerling BM. Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy. Mol Cell. 2018 May 3;70(3):531-544.e9.

Hopkins BD, Pauli C, Xing D, Wang DG, Li X, Wu D, Amadiume SC, Goncalves MD, Hodakoski C, Lundquist MR, Bareja R, Ma Y, Harris EM, Sboner A, Beltran H, Rubin MA, Mukherjee S, Cantley LC. Suppression of insulin feedback enhances the efficacy of PI3K inhibitors. Nature. 2018 Aug;560(7719):499-503. doi: 10.1038/s41586-018-0343-4. Epub 2018 Jul 4.

Goncalves MD, Cantley LC. A Glycolysis Outsider Steps into the Cancer Spotlight. Cell Metab. 2018 Jul 3;28(1):3-4. doi: 10.1016/j.cmet.2018.06.017.

Darragh F Halpenny, Marcus Goncalves, Emily Schwitzer, Jennifer Golia Pernicka, Jasmyne Jackson, Stephanie Gandelman, Chaya S. Moskowitz, Michael Postow, Marina Mourtzakis, Bette Caan, Lee W Jones, Andrew J Plodkowski.  Computed tomography derived assessments of regional muscle volume: Validating their use as predictors of whole body muscle volume in cancer patients. Br J Radiol, 2018; 91:20180451

Marcus D. Goncalves, Benjamin D. Hopkins, and Lewis C. Cantley. PI 3-Kinase, Growth Disorders, and Cancer. N Engl J Med 2018; 379:2052-2062

2017

Torigian DA, Green-McKenzie J, Liu X, Shofer FS, Werner T, Smith CE, Strasser AA, Moghbel MC, Parekh AH, Choi G, Goncalves MD, Spaccarelli N, Gholami S, Kumar PS, Tong Y, Udupa JK, Mesaros C, Alavi A. A Study of the Feasibility of FDG-PET/CT to Systematically Detect and Quantify Differential Metabolic Effects of Chronic Tobacco Use in Organs of the Whole Body-A Prospective Pilot Study. Acad Radiol. 2017 Aug;24(8):930-940.

Goncalves MD, Taylor S, Halpenny DF, Schwitzer E, Gandelman S, Jackson J, Lukose A, Plodkowski AJ, Tan KS, Dunphy M, Jones LW, Downey RJ. Imaging skeletal muscle volume, density, and FDG uptake before and after induction therapy for non-small cell lung cancer. Clin Radiol. 2018 May;73(5):505.e1-505.e8.

Goncalves MD, Green-McKenzie J, Alavi A, Torigian DA. Regional Variation in Skeletal Muscle and Adipose Tissue FDG Uptake Using PET/CT and Their Relation to BMI. Acad Radiol. 2017 Oct;24(10):1288-1294. doi: 10.1016/j.acra.2017.04.010. Epub 2017 May 24.

Torigian DA, Green-McKenzie J, Liu X, Shofer FS, Werner T, Smith CE, Strasser AA, Moghbel MC, Parekh AH, Choi G, Goncalves MD, Spaccarelli N, Gholami S, Kumar PS, Tong Y, Udupa JK, Mesaros C, Alavi A. A Study of the Feasibility of FDG-PET/CT to Systematically Detect and Quantify Differential Metabolic Effects of Chronic Tobacco Use in Organs of the Whole Body-A Prospective Pilot Study. Acad Radiol. 2017 Aug;24(8):930-940. 

2016

Hopkins BD*, Goncalves MD*, Cantley LC. Obesity and Cancer Mechanisms: Cancer Metabolism. J Clin Oncol. 2016 Dec 10;34(35):4277-4283. Epub 2016 Nov 7. Review.
*authors contributed equally 

2014

Goncalves MD, Alavi A, Torigian DA. FDG-PET/CT assessment of differential chemotherapy effects upon skeletal muscle metabolism in patients with melanoma. Ann Nucl Med. 2014 May;28(4):386-92.

2012

Lamming DW, Ye L, Katajisto P, Goncalves MD, Saitoh M, Stevens DM, Davis JG, Salmon AB, Richardson A, Ahima RS, Guertin DA, Sabatini DM, Baur JA. Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.Science. 2012 Mar 30;335(6076):1638-43

2011

Pistilli EE, Bogdanovich S, Goncalves MD, Ahima RS, Lachey J, Seehra J, Khurana T. Targeting the activin type IIB receptor to improve muscle mass and function in the mdx mouse model of Duchenne muscular dystrophy. Am J Pathol. 2011 Mar;178(3):1287-97. doi: 10.1016/j.ajpath.2010.11.071.

2010

Goncalves MD, Pistilli EE, Balduzzi A, Birnbaum MJ, Lachey J, Khurana TS, Ahima RS. Akt deficiency attenuates muscle size and function but not the response to ActRIIB inhibition. PLoS One. 2010 Sep 15;5(9):e12707

2009

Akpan I*, Goncalves MD*, Dhir R, Yin X, Pistilli EE, Bogdanovich S, Khurana TS, Ucran J, Lachey J, Ahima RS. The effects of a soluble activin type IIB receptor on obesity and insulin sensitivity. Int J Obes (Lond). 2009 Nov;33(11):1265-73.
*authors contributed equally